ВРОЛИЙК Николас (US),ХАНКО Джейсон (US),ЭНДЖЕРС Дэвид Алан (US),ХЭЙДЖЕН Эрик (US),СМОЛЕНСКАЯ Валерия (US),СТАЛТС Джеффри Скотт (US),НАРИНГРЕКАР Виджай Харишчандра (US),ПЕЙКОВ Виктор Цатчев (US),ФОСС В
申请号：
RU2013105700/04
公开号：
RU2013105700A
申请日:
2011.07.12
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. Crystalline Form C of Romidepsin. 2. Crystalline Form D of Romidepsin. 3. Crystalline Form E of Romidepsin. 4. Crystalline Form F of Romidepsin. 5. Crystalline Form H of Romidepsin. 6. Crystalline Form I of Romidepsin. 7. Crystalline Form J of Romidepsin. 8. Crystalline Form K of Romidepsin. 9. Crystalline Form L of Romidepsin. 10. Crystalline Form N of Romidepsin. 11. A method for preparing a lyophilized romidepsin / povidone composition comprising a final drying step, wherein the final drying temperature is from about 50 ° C to about 70 ° C, and the final drying time is from about 12 to about 36 hours. The method according to claim 11, according to which the ratio of romidepsin / povidone is 1: 2.13. The method according to claim 11, according to which the ratio of romidepsin / povidone is 1: 1.14. The method according to claim 12 or 13, wherein the final drying temperature is 50 ° C and the final drying time is 24 hours. The method according to claim 12 or 13, wherein the final drying temperature is 60 ° C and the final drying time is 24 hours. The method of claim 12 or 13, wherein the final drying temperature is 50 ° C. and the final drying time is 36 hours. The method of claim 12 or 13, wherein the final drying temperature is 60 ° C and the final drying time is 36 hours. A method of obtaining a lyophilized composition of romidepsin / povidone, comprising the stage of final drying, where the ratio of romidepsin / povidone is 1: 2； where the temperature of the final drying is 50 ° C； where the time of final drying is 36 hours； where the pressure is over�1. Кристаллическая форма С ромидепсина.2. Кристаллическая форма D ромидепсина.3. Кристаллическая форма Е ромидепсина.4. Кристаллическая форма F ромидепсина.5. Кристаллическая форма Н ромидепсина.6. Кристаллическая форма I ромидепсина.7. Кристаллическая форма J ромидепсина.8. Кристаллическая форма К ромидепсина.9. Кристаллическая форма L ромидепсина.10. Кристаллическая форма N ромидепсина.11. Способ получения ко
