INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - INRA
发明人:
MARC ANTON,CLAUDE GENOT,OSCAR CASTELLANI,LIONEL BRETILLON,JEAN-MICHEL CHARDIGNY
申请号：
FR1260928
公开号：
FR2998175A1
申请日:
2012.11.16
申请国别(地区):
FR
年份:
2014
代理人:
摘要：
The present invention relates to a process for the manufacture of a powdered dry emulsion, containing at least one lipophilic active ingredient, which comprises the following steps: (a) a step of providing two phases: (i) an aqueous phase containing at least one less an emulsifier compound of protein nature, and (ii) a lipid phase containing said lipophilic active ingredient (s), (b) a step of forming an oil-in-water emulsion comprising (i) a continuous phase constituted by said phase and (ii) a discontinuous phase constituted by said lipid phase, dispersed in the form of lipid particles having a maximum size of less than 3 μm, the interface of said lipid particles with the aqueous continuous phase comprising at least one or more emulsifying compounds of a nature protein, (c) a step of incorporating at least one saccharide compound, into said oil-in-water emulsion from step (b), and (d) a step of removing said aqueous phase in said oil-in-water emulsion resulting from step (c), for obtaining said powdered dry emulsion comprising said lipid particles containing said lipophilic active principle (s) and whose interface is covered with a secondary protective zone, said interface and said secondary protective zone comprising, respectively, said one or more emulsifying compounds of protein nature and / or said one or more saccharide compounds.La présente invention concerne un procédé pour la fabrication d'une émulsion sèche en poudre, contenant au moins un principe actif lipophile, qui comprend les étapes suivantes :(a) une étape de fourniture de deux phases : (i) une phase aqueuse contenant au moins un composé émulsifiant de nature protéique, et (ii) une phase lipidique contenant ledit ou lesdits principes actifs lipophiles,(b) une étape de formation d'une émulsion huile-dans-eau comprenant (i) une phase continue constituée par ladite phase aqueuse et (ii) une phase discontinue constituée par ladite phase lipidique, dispersée sous forme de particules lipidiques présentan
