CDK抑制劑和溶瘤病毒在製備抗腫瘤藥物的用途农业专利-农业学术服务平台

发明人:: YAN, GUANGMEI,颜光美,顏光美,ZHANG, HAIPENG,张海鹏,張海鵬,ZHU, WENBO,朱文博,朱文博,LIN, YUAN,林园,林園,LIANG, JIANKAI,梁剑开,梁劍開,CAI, JING,蔡静,蔡靜,GONG, SHOUFANG,龚守芳,龔守芳

摘要：: An application of a CDK inhibitor and an oncolytic virus in the preparation of an antitumor drug. A CDK inhibitor can be used in the preparation of an oncolytic virus-based antitumor potentiator. Provided are a pharmaceutical composition comprising the CDK inhibitor and the oncolytic virus, a drug kit comprising the CDK inhibitor and the oncolytic virus, and a use of the CDK inhibitor and the oncolytic virus in the treatment of tumors, particularly the tumors not sensitive to the oncolytic virus.本發明屬於生物醫藥領域，涉及CDK(cyclin-dependent kinase，週期蛋白依賴性激酶)抑制劑和溶瘤病毒在製備抗腫瘤藥物的用途。本發明首次發現CDK抑制劑可以用於製備溶瘤病毒抗腫瘤增效劑。發明同時涉及一種包含CDK抑制劑以及溶瘤病毒的藥物組合物，包含CDK抑制劑及溶瘤病毒的藥品套組，以及CDK抑制劑與溶瘤病毒在治療腫瘤，特別是對所述溶瘤病毒不敏感的腫瘤中的用途。