WEINBACH, SUSAN P.,TILLMAN, LLOYD G.,GEARY, RICHARD S.,HARDEE, GREGORY E.
申请号：
CA2458442
公开号：
CA2458442C
申请日:
2002.08.22
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Modified release pharmaceutical formulations and methods for enhanced mucosaldrugabsorption. The formulation comprises initial population(s) of particlescomprising both drug andpenetration enhancer which are released at a first location in thegastrointestinal tract, and asubsequent population or populations of particles comprising a penetrationenhancer(s) having adelayed release due to a polymeric coating or matrix. This penetrationenhancer is released at anadditional location(s) in the intestine downstream from the first location andenhances absorption ofthe drug when it reaches the additional location(s).
