Methods for altering the immune response elicited by CpG oligodeoxynucleotides

• 收藏
• 分享

专利权人:

アメリカ合衆国

发明人:

クリンマン デニス エム．,ギュルセル マイダ,ギュルセル イーサン,クリンマン デニス エム.

申请号：

JP2008529207

公开号：

JP5481068B2

申请日:

2006.08.28

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

It is disclosed herein that agents that affect the activity and/or expression of CXCL16 can be used to alter the uptake of D-type CpG oligodeoxynucleotides (D ODNs). Methods of inducing an immune response are disclosed that include administering agents that increase the activity and/or expression of CXCL16 and a D ODN. Methods of decreasing an immune response to a CpG ODN are also disclosed. These methods include administering an agent that decreases the activity and/or expression of CXCL16. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression of CXCL16 are provided.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/