Provided herein are PD-1 antigen-binding proteins and related nucleic acids, vectors, host cells, kits and pharmaceutical compositions. Methods of making PD-1 antigen-binding proteins and methods of treating a subject are further provided.本文提供PD-1抗原結合蛋白及相關核酸、載體、宿主細胞、套組及醫藥組合物。進一步提供製造PD-1抗原結合蛋白之方法,以及治療個體之方法。