Ahmed Hamdy,Wayne Rothbaum,Raquel Izumi,Brian Lannutti,Todd Covey,Roger Ulrich,Dave Johnson,Tjeerd Barf,Allard Kaptein
申请号：
US16298094
公开号：
US20190290644A1
申请日:
2019.03.11
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Therapeutic methods of treating chronic lymphocytic leukemia (CLL) and small lymphocytic leukemia (SLL) are described. In certain embodiments, the invention includes therapeutic methods of treating CLL and SLL using a BTK inhibitor. In certain embodiments, the invention includes therapeutic methods of treating subtypes of CLL and SLL using a BTK inhibitor, including subtypes of CLL in patients sensitive to thrombosis and subtypes of CLL that increase monocytes and NK cells in peripheral blood after treatment with a BTK inhibitor. In certain embodiments, the invention includes therapeutic methods of treating CLL and SLL using a combination of a BTK inhibitor and an anti-CD20 antibody.
