A composition is provided for transgenic plants and transgenic plant derived human coagulation factors capable of eliciting an activation response in human blood clotting pathways and therefore useful for the treatment of human beings diagnosed to be deficient in blood clotting factor proteins. Such proteins may be manufactured by methods resulting in viral free production using both whole plants and plant cell cultures. Also provided are expression vectors for the proper transformation of plant tissue for the production of such factors, as well as transformed plant cells and processes for producing human coagulation factors using plant molecular biology techniques.
