ALESSANDRO ACCETTA,ANNA MARIA CAPELLI,ARNAUD JEAN FRANCOIS AUGUSTE CHEGUILLAUME,,CHRISTINE EDWARDS,DAVID EDWARD CLARK,FABIO RANCATI,GURDIP BHALAY,PATRIZIA TISSELLI
申请号：
BR112019015707
公开号：
BR112019015707A2
申请日:
2018.01.26
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
the present invention relates to compounds of formula (i) which inhibit rho-kinase and are bicyclic dihydropyrimidine carboxamide derivatives, the methods of preparing such compounds, the pharmaceutical compositions containing them and their therapeutic use. the compounds of the invention can be particularly useful in the treatment of many disorders associated with the enzymatic mechanisms of rock, such as lung diseases, including asthma, chronic obstructive pulmonary disease (dpoc), idiopathic pulmonary fibrosis (ipf) and pulmonary arterial hypertension (pah).a presente invenção se refere a compostos de fórmula (i) que inibem a rho-quinase e são derivados di-hidropirimidino-carboxamídicos bicíclicos, os métodos de preparação de tais compostos, as composições farmacêuticas que os contêm e o uso terapêutico destes. os compostos da invenção podem ser particularmente úteis no tratamento de muitos distúrbios associados aos mecanismos enzimáticos de rock, tais como doenças pulmonares, incluindo asma, doença pulmonar obstrutiva crônica (dpoc), fibrose pulmonar idiopática (ipf) e hipertensão arterial pulmonar (pah).
