Drug delivery systems are provided that include an actuator assembly (200) permanently attached to a filter (300) for connection of a container containing medications such as epidural anesthesia, to a delivery site. The actuator assembly has a distal end, a proximal end, a projection including an opening attached at the distal end of the actuator assembly and extending in a proximal direction from the distal end of the actuator assembly, a hub attached to the distal end of the actuator assembly and disposed in a coaxial relationship with the projection, and a filter including an inlet that is integrally permanently glued or welded to the base of the hub attached to the distal end of the actuator assembly and an outlet in fluid communication with the inlet and the opening. The filter is disposed along a first axis. The system also includes a conduit attached to the outlet of the filter for attachment of the drug delivery system to a delivery site.
