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LIPOSOMAL FORMULATIONS OF ANTHRACYCLINE AGENTS AND CYTIDINE ANALOGS
专利权人:
CELATOR PHARMACEUTICALS; INC.
发明人:
LAWRENCE MAYER,SHARON JOHNSTONE,TROY HARASYM
申请号:
PT05738885
公开号:
PT1744764E
申请日:
2005.04.22
申请国别(地区):
PT
年份:
2012
代理人:
摘要:
Provided is a composition suitable for parenteral administration to a subject, which composition comprises daunorubicin and cytarabine encapsulated in liposomes in a mole ratio of daunorubicin:cytarabine of about 1:5, wherein said liposomes have a mean diameter in the range of 4.5 nm to less than 250 nm and wherein the pharmacokinetics of the composition are controlled by the liposomes, whereby the daunorubicin and cytarabine agents are to be delivered to a disease site in a coordinated fashion, thereby assuring that said ratio is maintained at the disease site.
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