This present invention relates to novel Lubiprostone crystals and methods for preparing the same. The preparation methods provided by the invention can effectively reduce or eliminate impurity in the obtained Lubiprostone crystals.本發明係關於新穎的魯比前列酮(Lubiprostone)晶體及其製備方法。本發明提供之製備方法可有效地減少或除去所獲得的魯比前列酮晶體中之雜質。