1. The application refers to the acceptable compounds and ingredients on drugs that can be used as inhibitors in Iraq. 1. Claim 1: a formula compound (1),Or a pharmaceutically acceptable salt, where x is Cr or N, a is O, s, so832222,SO -NRC (O)-NRSO o N (R)Or absent； R3 is - R, halogen, halogen, or, sir, CN, N, N, n-SO R -SOR -C (O) R -CO R -C (O) N (R)-NRC (O) R -NRC (O) N (R)-So8322； R-N (R) 832222；Or when a is - NRC (o),-NRSO o N (R)Then R and RConnected with each atom, they can form a heteromorphic ring composed of 3 to 7 members, 1 to 4 heteromorphic atoms independently selected from nitrogen, oxygen or sulfur, or a single heterocyclic ring composed of 5 to 6 members, and 1 to 4 heteromorphic atoms independently selected from nitrogen. Oxygen or sulfur, each of which is optional； X is Cr or N； Z ring is a heterocyclic ring composed of 3 to 7 members, consisting of 1 to 4 heteroatoms independently selected from nitrogen, oxygen or sulfur,Or a single ring with 5 to 6 members, which is composed of 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur, each of which can be replaced optionally； R1 es-r, halogen, halide, or, sir, CN, no.83222；-SO R -SOR -C (O) R -CO R -C (O) N (R)-NRC (O) R -NRC (O) N (R)-So8322； R-N (R) 832222；R74919 is missing R, halogen, halogen, or, sir, CN, no832222,-SO R -SOR -C (O) R -CO R -C (O) N (R)-NRC (O) R -NRC (O) N (R)-So8322； R-N (R) 832222；a. Ring y is a selective heterocyclic ring, which consists of 5-6 members and 2-4 heteroatoms, selected from nitrogen, oxygen o r sulfur, R 2 es-r, halogen, halide, o r, Sr, CN, no832222；-SO R -SOR -C (O) R -CO R -C (O) N (R)-NRC (O) R -NRC (O) N (R)-So8322； R-N (R) 832222；R74955 no r, halogen, halogen, or, sir, CN, no832222,-SO R -SOR -C (O) R -CO R -C (O) N (R)-NRC (O) R -NRC (O) N (R)-So8322； R-N (R) 832222；each R is independently hydrogen, aliphatic C₁₋₆,aryl C₃₋₁₀,A saturated or partially unsaturated carbon thyroid ring, consisting of 3 to 8 members, 3 to 7 members, and 1 to 4
