Juan Andres Asturias,Alberto Martinez Garate,Roberto Gonzales Rioja
申请号：
US14198293
公开号：
US20140286972A1
申请日:
2014.03.05
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to recombinant DNA molecules which encode chimeric polypeptides of differing allergens of Parietaria judaica which can be used for the prevention and treatment of allergies, in particular pollen allergies. Specifically, chimeric polypeptides composed of fragments of the allergens Par j 1 and Par j 2 having hypoallergenic characteristics are described. Methods for producing these recombinant polypeptides in heterologous expression systems are also described. Efficient methods of purifying the chimeric proteins are also described.
