The present invention relates to a method for producing a purified gold and silver flower extract and a composition for preventing and treating sepsis and septic shock including the same. The purified gold and silver flower extract according to the present invention is used in terms of severe sepsis CLP model test, influence on MODS, and inhibitory effect of various inflammatory cytokines such as TNF-α, IL-1β, IFN-γ, and HMGB-1. It exhibits potent anti-septic activity and, when used with a commercially available anti-septic agent such as a broad spectrum antibiotic, shows an unexpected synergistic effect in the treatment of sepsis and septic shock, and is used as a pharmaceutical and health functional food. And can be effectively used for the treatment and prevention of septic shock. [Selection] Figure 2本発明は、金銀花精製抽出物の製造方法及びそれを含む敗血症及び敗血症性ショックの予防及び治療用組成物に関する。本発明による金銀花精製抽出物は、重症敗血症ＣＬＰモデルテスト、ＭＯＤＳへの影響、及びＴＮＦ‐α、ＩＬ‐１β、ＩＦＮ‐γ、ＨＭＧＢ‐１等の多様な炎症性サイトカインの抑制効果の面で強力な抗敗血症活性を見せ、また、広範囲抗生剤のような市販の抗敗血症剤とともに使用したとき、敗血症及び敗血症性ショックの治療に予想外の相乗効果を見せ、医薬品及び健康機能性食品として敗血症及び敗血症性ショックの治療及び予防に有効に使用することができる。【選択図】図２
