Randall BURTON,Jessie M. ENGLISH,Barbara S. FOX,Stavros KOPSIAFTIS,Yacob GOMEZ LLORENTE,Renee MOORE,Patricia RAO,Giovanna SCAPIN,Kenneth J. SIMON,Haihong ZHOU
申请号：
US16597593
公开号：
US20200140530A1
申请日:
2019.10.09
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein are anti-LAP antibodies (e.g., recombinant humanized, chimeric, and human anti-LAP antibodies) or antigen binding fragments thereof which have therapeutically beneficial properties, such as binding specifically to LAP-TGFβ1 on cells but not to LAP-TGFβ1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies or antigen binding fragments in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.
