The present disclosure provides a patient positioning device and methods of using such a device that allows for the easy securing of the device to the operating room table or hospital bed, a comfortable surface for patients to rest on during their diagnostic, therapeutic or surgical procedure, that helps reduce the likelihood of developing pressure ulcers, protects the patient by providing an infectious barrier, helps protects the patient from electrical injury by creating a non-conductive barrier between the patient the metal operating table, and protects the operating room table and equipment with an integrated, impermeable barrier to prevent blood, other bodily fluids and other fluids such as intravenous fluids, blood products and irrigation from soiling the operating or procedure table and nearby equipment. The device overcomes several challenges that exist with current devices and methods and is simple, disposable, and cost-effective. It allows for easier, faster and safer patient positioning, improved infection control, lower risk of electrical injury, improved protection from pressure ulcer formation, less waste compared to current options in a single, one-package solution. Additionally, a leg portion of the device can include an inflatable member which serves as a Sequential Compression Device which can be repeatedly inflated/deflated to facilitate circulation and prevent formation of blood clots.