CASIMIRO DANILO R,BETT ANDREW,COLLER BETH ANN GRISWOLD,DHANASEKARAN GOVINDARAJAN,CHINTALA RAMESH V
申请号：
IN201747019185
公开号：
IN201747019185A
申请日:
2017.05.31
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The present invention relates to dengue virus vaccine compositions comprising a first and a second dengue vaccine wherein the first dengue vaccine comprises at least one live 5 attenuated dengue virus or live attenuated chimeric dengue virus and the second dengue vaccine is a recombinant dengue subunit vaccine a DNA vaccine a conjugate vaccine or an inactivated dengue vaccine wherein the genome of the live attenuated dengue virus or the live attenuated chimeric dengue virus comprises a 30 nucleotide deletion of the TL2 stem loop structure of the 3 untranslated region. The dengue virus vaccine compositions of the invention may further 10 comprise one or more adjuvants. In preferred embodiments of the invention the first and the second dengue vaccine are tetravalent. The invention also relates to methods of using the dengue virus vaccine compositions of the invention to treat or prevent dengue infection or to prevent ameliorate or delay the onset or progression of the clinical manifestations thereof.
