Phosphorylated peptides and hard tissue and / or ectopic calcification inhibitors

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专利权人:

株式会社ラフィーネインターナショナル;国立大学法人広島大学

发明人:

吉子 裕二,南崎 朋子,吉岡 広陽,平田 伊佐雄,香西 克之,前田 憲彦,渡邉 和晃,清藤 勉

申请号：

JP2011150487

公开号：

JP5950380B2

申请日:

2011.07.06

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

Provided are a phosphorylated peptide having the effect of inhibiting hard tissue and/or ectopic calcification using the active sites for a calcification inhibiting effect of MEPE-derived ASARM peptide, a hard tissue and/or ectopic calcification inhibitor, antibody having a hard tissue and/or ectopic calcification-promoting effect, and a hard tissue and/or ectopic calcification promoter. The phosphorylated peptide is characterized in that the peptide has the entire or partial amino acid sequence of MEPE-derived ASARM peptide, at least two of the amino acid residues in the amino acid sequence are phosphorylated serine, and the peptide has a hard tissue and/or ectopic calcification-inhibiting effect. The antibody is characterized in recognizing phosphorylated serine, which is the active center of the phosphorylated peptide.

来源网站：

中国工程科技知识中心

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