АЛЕНФОЛ Ян (SE),ДУНЕР Понтус (SE),ХУЛЬТГАРДХ НИЛЬСОН Анна (SE)
申请号：
RU2014108819/10
公开号：
RU2014108819A
申请日:
2012.08.10
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. Composition for stimulating hair growth in mammals, comprising: a) a modified osteopontin polypeptide in which the RGD domain is inactivated, and b) a pharmaceutically acceptable and / or cosmetically acceptable excipient, carrier or solvent. The composition of claim 1, wherein the polypeptide has the property of stimulating human hair growth. The composition of claim 1, wherein the polypeptide has the property of stimulating hair growth in vivo. A composition according to claim 1, wherein the polypeptide has the property of stimulating existing hair follicles. The composition of claim 1, wherein the polypeptide has the ability to induce the formation of new hair follicles or stem cells forming such follicles. The composition of claim 1, wherein the length of the polypeptide corresponds to less than 500 amino acid residues, for example, less than 400, 350, 340, 330, 320, 310, 300, 290, 280, 270, 260, 250, 200, 150, 100 50, 40, 30, 20, 15, 10 or less amino acid residues. 7. The composition of claim 6, wherein the polypeptide is a long polypeptide of 250-350 amino acids, for example, 280-300 amino acids. The composition of claim 7, wherein the polypeptide is 293 amino acids in length. The composition of claim 1, wherein the RGD domain in the modified osteopontin polypeptide is mutated at one or more amino acids. The composition of claim 1, wherein the RGD domain of the modified osteopontin polypeptide is deleted at least in part. The composition of claim 1, wherein the RGD domain in the modified osteopontin polypeptide comprises a substitution of one or more amino acids. The composition of claim 1, wherein the modified osteopontin polypeptide comprises or consists of the amino acid sequence of SEQ ID NO: 1: MRLAVICFCLF1. Композиция для стимулирования роста волос у млекопитающих, содержащая:a) модифицированный полипептид остеопонтина, в котором RGD домен инактивирован, иb) фармацевтически приемлемый и/или косметически приемлемый наполнитель, носитель или растворител
