Heidi Alexandra Lane,Felix Bachmann,Madlaina Breuleux,Michael Boutros,Daniel Gilbert,Xian Zhang
申请号：
US15060998
公开号：
US20160320397A1
申请日:
2016.03.04
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Use of BUBR1 as a biomarker for predicting the response to a compound, preferably resistance of a disease such as cancer in a subject, wherein the compound is a compound of general formula IwhereinR represents phenyl, thienyl or pyridinylwherein phenyl is optionally substituted by one or two substituents independently selected from alkyl, halo-lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, acyloxy-lower alkyl, phenyl, hydroxy, lower alkoxy, hydroxy-lower alkoxy, lower alkoxy-lower alkoxy, phenyl-lower alkoxy, lower alkylcarbonyloxy, amino, monoalkylamino, dialkylamino, lower alkoxycarbonylamino, lower alkylcarbonylamino, substituted amino wherein the two substituents on nitrogen form together with the nitrogen heterocyclyl, lower alkylcarbonyl, carboxy, lower alkoxycarbonyl, cyano, halogen, and nitro and wherein two adjacent substituents are methylenedioxyand wherein pyridinyl is optionally substituted by lower alkoxy, amino or halogenX represents a group C═Y, wherein Y stands for oxygen or nitrogen substituted by hydroxy or lower alkoxyR1 represents hydrogen, lower alkylcarbonyl, hydroxy-lower alkyl or cyano-lower alkylR2, R3 and R6 represent hydrogenR4 and R5, independently of each other, represent hydrogen, lower alkyl or lower alkoxyor R4 and R5 together represent methylenedioxyand pharmaceutically acceptable derivatives thereofor whereinR represents phenyl or pyridinylwherein phenyl is optionally substituted by one or two substituents independently selected from alkyl, halo-lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, acyloxy-lower alkyl, phenyl, hydroxy, lower alkoxy, hydroxy-lower alkoxy, lower alkoxy-lower alkoxy, phenyl-lower alkoxy, lower alkylcarbonyloxy, amino, monoalkylamino, dialkylamino, lower alkoxycarbonylamino, lower alkylcarbonylamino, substituted amino wherein the two substituents on nitrogen form together with the nitrogen heterocyclyl, lower alkylcarbonyl, carboxy, lower alkoxycarbonyl, formyl, cyano, halogen, and ni
