YU, Henry,RICHARDSON, Thomas E.,BHARATHI, Pandi,HEASLEY, Brian H.,JENKS, Matthew G.,FOGLESONG, Robert J.
申请号：
ES13700819
公开号：
ES2663972T3
申请日:
2013.01.09
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Compounds of formula (I) ** (See formula) ** where W1, W2 denotes N； R1 denotes - (CY2) nE-Het3, - (CY2) n-Cyc-Het3, - (CY2) n-Het1, - (CY2) n-CONH-Het1, - (CY2) n-NHCO-Het1, - ( CY2) n-Cyc, - (CY2) n-CONH-Cyc, - (CY2) n-NHCO-Cyc, A, - (CYR8) n-OY, - (CY2) n-COOY, - (CY2) n- SO2Y, - (CYR8) n-CONY2, - (CYR8) n-NY2, - (CYR8) n-NYCOY, - (CY2) n-NYCOOY, - (CY2) n-NYCONY2 or - (CY2) n-NHCO- CH>； = CH2； R2 denotes H； R1, R2 together also denote - (CY2) P-NH- (CY2) P-, - (CY2) p-NHCO- (CY2) p-, - (CY2) p-CONH- (CY2) p-, - ( CY2) pN (COA) - (CY2) p-, - (CY2) pN (COOA) - (CY2) p-, ** (See formula) ** R3 denotes furyl or oxazolyl, which may be monosubstituted with A or Cyc ； R4 denotes H； R5 denotes phenyl, which may be mono or disubstituted with A or Hal, or pyridyl, which may be monosubstituted with A or Hal； R6, R7 together denote - (CY2) 2-； R8 denotes Y or Ar； R9 denotes Y； R10 denotes Hal, Y, OY, -O (CY2) n-OY, NY2, Cyc, COOY, CONH2, NHCOY or CN； with the proviso that R 9 and R10 are not simultaneously H； R2, R10 together also denote - (CY2) P- or - (CY) 2-； X denotes CO； E denotes - (CY2) m-, O, CO, -COO- or SO2； And denotes H or A； A denotes unbranched or branched alkyl with 1-10 C atoms, where 1-7 H atoms can be independently replaced by Hal and / or>； = O； Cyc denotes cycloalkyl with 3-6 C atoms, where 1-3 H atoms can be replaced independently of each other by OH or COOH； Ar denotes an unsaturated or aromatic mono or bicyclic carbocycle with 3-10 C atoms, which may be substituted with at least one substituent selected from the group consisting of A, Hal, OY, COOY, CONH2, NHCOY, - (CY2) n -NY2, NO2, SO2Y, CN and Het2, or that can be merged into Cyc； Het1 denotes an unsaturated or aromatic mono or bicyclic heterocycle with 1-10 atoms of C and 1-4 atoms of N, O and / or S, which may be substituted with at least one substituent selected from the group consisting of Hal, A, Cyc, OY, COOY, CONH2, NHCOY, NY2, SO2Y, SO2NY2, NHSO2Y, CN and Ar； Het2 denotes a 5-membered u
