Sunghoon Kim,Jung Min Han,Hyeong Rae Kim,Dong Ju Jeon,Jong Hwan Song,Kyung Eun Park
申请号：
US13505651
公开号：
US20120322802A1
申请日:
2010.11.02
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to novel 2,4-pyrimidine derivatives and a use thereof, and more particularly, to pyrimidine derivatives which are effective for systemic lupus erythematosus, a composition for preventing and treating systemic lupus erythematosus comprising the same as an active ingredient and a method for screening the same. The present inventors found novel materials inhibiting surface translocation of gp96 by mimicking a function of AIMP1 which is a molecular anchor for an intracellular residence of gp96, and identified in vitro and in vivo activity of the materials for preventing and treating SLE by alleviating SLE plasma in autoimmune diseases. Therefore, the present invention provides a novel method for screening a therapeutic agent for SLE, and preventing or treating SLE using the mechanism.
