The present invention relates to a composition for improving inflammatory disease, and more specifically to a composition for improving inflammatory disease able to improve inflammatory reactions and the barrier function of epithelial tissue such as the skin, to enhance aging resistance and skin elasticity and to prevent or treat aging. The present invention makes it possible to control inflammatory reactions by modulating the expression and modulating the activity of ABH antigens, and thus the composition of the present invention can be employed as a development marker for therapeutic agents designed to soothe or treat or help in the treatment of disease caused by inflammatory reaction in body tissue and notably the skin expressed by ABH antigens, and can be used in the development of external preparations and cosmetics containing external preparations designed for the purposes such as restoration of normal function and moisturization, wrinkle enhancement, whitening and elasticity recovery in skin through modulation of differentiation of keratinocytes and the skin barrier function.本発明は、炎症疾患改善用組成物に関し、より詳しくは、皮膚のような上皮組織における炎症反応及び障壁機能改善と、抗老化、皮膚弾力の強化、及び老化を予防又は治療することのできる炎症疾患改善用組成物に関する。本発明によれば、ＡＢＨ抗原の発現調節及び活性調節を介し炎症反応を制御することができるので、本発明の組成物は、ＡＢＨ抗原が発現される皮膚を始めとする人体組織における炎症反応が原因になる疾患の鎮静や治療、及び治療補助を目的とする治療剤の開発標的に活用することができ、さらに角質形成細胞の分化及び皮膚障壁機能の調節による皮膚の正常機能回復及び保湿、しわの改善、美白、弾力の回復などを目的にする外用剤及び外用剤成分を含む化粧品の開発に用いられ得る。
