Dutch Renewable Energy B.V.;Hubert Clemens PELLIKAAN;Rolf Lourens VISSER
发明人:
Hubert Clemens PELLIKAAN,Rolf Lourens VISSER
申请号：
IL26906919
公开号：
IL269069D0
申请日:
2019.09.02
申请国别(地区):
IL
年份:
2019
代理人:
摘要：
The present invention relates to a method for administering water soluble physiologically active substances, said method comprising intranasally administering to a subject an aqueous composition comprising 0.001-25 wt. % of one or more fully dissolved physiologically active substances, the physiologically active substances having a water solubility in demineralized water of at least 15 mg/mL at 20° C. of, 0.01-10 wt. % nicotinamide, and at least 60 wt. % water. The invention also relates to a kit comprising said composition and to the use of nicotinamide as an enhancer of intranasal absorption of a physiologically active substance from an aqueous solution, wherein the aqueous solution further comprises 0.01-10 wt. % nicotinamide.
