Mohan Srinivasan;Josephine M. Cardarelli;Alison Witte
发明人:
Josephine M. Cardarelli,Alison Witte,Mohan Srinivasan
申请号：
US12704948
公开号：
US08460668B2
申请日:
2010.02.12
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and that are capable of inhibiting the biological activity of Type I interferons. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting Type I interferon-mediated disorders using the antibodies of the invention, including methods for treating autoimmune disorders, transplant rejection or Graft Versus Host Disease using the antibodies of the invention.
