The embodiments include preventing or reducing the progression of prostatecancer in mammals susceptible todeveloping prostate cancer, and reducing the incidence of clinically detectedprostate cancer, using compositions containing compoundsbased on small neural thread peptides based on SEQ. ID. NO. 66(IDQQVLSRIKLEIKRCL) and a pharmaceutically acceptable carrier.The embodiment includes, but is not limited to, administering the compoundsintramuscularly, orally, intravenously, intraprostatically,intrathecally, intratumorally, intranasally, topically, transdermally, etc.,either alone or conjugated to a carrier to a mammal in needthereof.