5-substituted benzofurans as inhibitors of cytochrome P450 2D6

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专利权人:

发明人:

Michael Eissenstat,Dehui Duan,Ji-Hye Kang

申请号：

US13854648

公开号：

US08791157B2

申请日:

2013.04.01

申请国别(地区):

US

年份:

2014

代理人:

摘要：

Methods of inhibiting cytochrome P450 2D6 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450 2D6. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 2D6 enzymes. The compositions comprise 5-substituted benzofuran compounds having the formula I:

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