Formulations to treat skin discoloration via a multi-modal approach are provided in which select ingredients work together to effectively brighten skin and treat hyperpigmentation. An example formulation includes a first anti-melanin agent, a second anti-melanin agent, an anti-inflammatory agent, a sun protection agent, and an anti-oxidant. In one aspect, the first anti-melanin agent comprises a bidens pilosa extract, the second anti-melanin agent comprises a rheum rhaponticum extract, the anti-inflammatory agent comprises a Vitamin E compound, the sun protection agent comprises zinc oxide and titanium dioxide, and the antioxidant comprises a thermus thermophilus ferment extract.
