Devices are provided herein for translumenal access to a treatment site within a body cavity. In general, the devices include an elongate sleeve configured to provide access to a treatment site wherein various portions of the sleeve are associated with an anti-microbial agent. Additionally, the anti-microbial agent(s) can be disposed within a housing and/or inner lumen of the sleeve such that surgical instruments passing therethrough can be sterilized en route to and/or being withdrawn from the treatment site. Additionally, various methods are also provided herein for maintaining the sterility of a treatment site.
