INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
Jae Wook YANG,Hye Sook LEE,Yoon Jin LEE,Chae Eun KIM,Hae Shin LEE,Whui Su SHIM,Moon Sue LEE
申请号：
US16488940
公开号：
US20190374531A1
申请日:
2017.08.02
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A composition for preventing or treating dry eye syndrome includes nanocomposite of a polyethylene glycol and a flavonoid as an active ingredient, and in the present invention, a catechin/PEG nanocomposite having increased catechin bioavailability is prepared by using catechins which are an antioxidant and polyethylene glycol which is a hydrophilic polymer used in a drug delivery system, and an increase in tear generation, stabilization of corneal epithelial cells, an increase in conjunctival goblet cells and enhanced anti-inflammatory effects accordance to a PEG dosage by the catechin/PEG nanocomposite are confirmed in a mouse model with dry eye syndrome.
