Methods of treating chronic rhinosinusitis are provided. The methods include topically administering a combination of antifungal agents to the ostiomeatal complex of a subject having chronic rhinosinusitis, the topically administering including contacting a first antifungal agent with the ostiomeatal complex, the first antifungal selected as effective at killing Candida species of fungus, inhibiting the growth and/or reproduction of the Candida species, or a combination thereof and, contacting a second antifungal agent with the ostiomeatal complex, the second antifungal selected as effective at killing an Aspergillus species of fungus, inhibiting the growth and/or reproduction of the Aspergillus species, or a combination thereof wherein, the topically administering of the first antifungal agent is concurrent with the topically administering of the second antifungal agent.
