DERIVES DE PIPERIDINE SPIRO-FUSIONNEE A UTILISER COMME INHIBITEURS DU CANAL POTASSIQUE MEDULLAIRE EXTERNE RENAL

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专利权人:

MERCK SHARP & DOHME CORP.

发明人:

DING, FA-XIANG,DONG, SHUZHI,FRIE, JESSICA,GU, XIN,JIANG, JINLONG,PASTERNAK, ALEXANDER,TANG, HAIFENG,WU, ZHICAI,YU, YANG,SUZUKI, TAKAO

申请号：

CA2876508

公开号：

CA2876508A1

申请日:

2013.07.25

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/