Frank Dininno,Milton L. Hammond,Kevin Dykstra,Seongkon Kim,Qiang Tan,Katherine Young,Jeffrey Donald Hermes,Helen Chen,Stephane Raeppel,Michael Mannion,Frederic Gaudette,Arkadii Vaisburg,Jubrail Rahil
申请号：
US12301797
公开号：
US08440643B2
申请日:
2007.05.21
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This invention provides novel β-lactamase inhibitors of the aryl- and heteroaryl-sulfonamidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammomium groups. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazimdime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases.
