ОЛИДЖИНО Томас (US),ХАН Чанг (US),ГИЛЛЕСПИ Тимоти А. (US),ДХАРАНИПРАГАДА Рамалинга (US),МАЦКИН Эллен (US)
申请号：
RU2010141560/15
公开号：
RU2010141560A
申请日:
2009.03.05
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A method of treating an ophthalmic disorder in a patient, comprising administering to the patient a pharmaceutically effective amount of a compound of formula I,! (I)! or a pharmaceutically acceptable salt or prodrug thereof. ! 2. The method according to claim 1, wherein the ophthalmic disorder is ophthalmic neovascularization. ! 3. The method according to claim 2, in which the ophthalmic disorder is an ophthalmic neovascularization of the retina. ! 4. The method according to claim 1, wherein the ophthalmic disorder is selected from: age-related macular degeneration, diabetic retinopathy and diabetic macular edema. ! 5. The method according to claim 4, in which the ophthalmic disorder is age-related macular degeneration. ! 6. The method according to claim 4, in which the ophthalmic disorder is diabetic retinopathy. ! 7. The method according to claim 4, in which the ophthalmic disorder is diabetic macular edema. ! 8. The method according to claim 1, in which the compound of formula I is administered to a patient who is simultaneously receiving treatment with ranizumab. ! 9. A pharmaceutical composition for treating age-related macular degeneration, diabetic retinopathy or diabetic macular edema, comprising a compound of formula I:! (I)! or a pharmaceutically acceptable salt or prodrug thereof. ! 10. The use of the compounds of formula I:! (I)! for the manufacture of a pharmaceutical composition for the treatment of age-related macular degeneration, diabetic retinopathy or diabetic macular edema. ! 11. A method for the treatment of age-related macular degeneration, diabetic retinopathy or diabetes1. Способ лечения офтальмологического расстройства у пациента, включающий введение пациенту фармацевтически эффективного количества соединения формулы I, ! (I) ! или его фармацевтически приемлемой соли или его пролекарства. ! 2. Способ по п.1, в котором офтальмологическим расстройством является офтальмологическая неоваскуляризация. ! 3. Способ по п.2, в котором
