CHENG, JYA WEI,程家维,程家維,CHU, HUNG LUN,祝宏伦,祝宏倫,CHIH, YA HAN,池雅涵,YU, HUI YUAN,游辉元,游輝元
申请号：
TW107106842
公开号：
TWI677508B
申请日:
2018.03.01
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
An anti-endotoxin polypeptide is provided. The anti-endotoxin polypeptide having the formula (I) KR12-L-C1, wherein C1independently is an amphipathic or hydrophobic short peptide with α-helix, L is AGP(Ala-Gly-Pro)or a peptide bond, and the hydrophobicity of the hydrophobic terminal in anti-endotoxin polypeptide is between about 0.425 and 0.765. The anti-endotoxin polypeptide of the invention can neutralize the lipopolysaccharide and has the low hemolysis and high salt resistance, simultaneously. The present invention also provides a method for design an anti-endotoxin polypeptide, the anti-endotoxic activity is adjusted through increasing and/or decreasing hydrophobicity of the hydrophobic terminal.本發明係提供一種抗內毒素多胜肽，其具有通式(I)KR12-L-C1結構，其中C1獨立地為具有α-螺旋結構的雙極性或疏水性短胜肽，L為Ala-Gly-Pro(AGP)或胜肽鍵，且其中疏水端(hydrophobic)的疏水性介於約0.425~0.765之間。本發明之抗內毒素多胜肽可中和脂多醣，且同時具有低溶血性及高耐鹽性。本發明另提供一種設計抗內毒素多胜肽的方法，上述抗內毒素胜肽之疏水端為具疏水性之官能基，並可藉由調整疏水端之係數調控抗內毒素胜肽的抗內毒素活性，其中該抗內毒素胜肽具殺菌及抗發炎之功效。
