FIONA BRABAZON,KIMBERLY BYRNES,LEAH RANAE BRESIN HANSON,WILLIAM H. FREY II
申请号：
BR112016023491
公开号：
BR112016023491A2
申请日:
2015.04.07
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present system is directed in several embodiments to a method of administration of a therapeutic composition for protection of the brain of a subject at risk of injury leading to traumatic brain injury (TBI) and/or treatment of injury to the brain resulting from TBI. The method includes administering one or more therapeutic compositions comprising an effective amount of insulin directly to the subject patients CNS, with no to minimal systemic exposure. Preferably, this method comprises administration of an effective amount of insulin to the upper third of a patients nasal cavity, thereby bypassing the patients blood-brain barrier and delivering the therapeutic composition directly to the patients central nervous system.
