An OCT probe for imaging patient tissue includes a probe housing, and includes a cannula extending from the probe housing and arranged to penetrate patient tissue. The cannula may include a main body segment and a distal segment. The main body segment may have a lumen defining a first central axis, and the distal segment may have a lumen defining a second central axis that is angled from the first central axis. A lens is disposed in the distal segment. The lens may have a proximal side and a distal side and an optical axis. The optical axis may be substantially parallel to the second central axis and may be angled relative to the first central axis.