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COPOLYMÈRE SÉQUENCÉ AMPHIPHILE ET SON PROCÉDÉ DE PRÉPARATION ET SYSTÈME MICELLAIRE CHARGÉ DE MÉDICAMENT FORMÉ PAR CELUI-CI ET COMPRENANT UN MÉDICAMENT ANTITUMORAL
专利权人:
Changzhou Target Medicine Technology Co.; Limited
发明人:
申请号:
EP13848829.1
公开号:
EP2913353B1
申请日:
2013.09.22
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present invention relates to a novel amphiphilic block copolymer and the preparation method thereof, as well as a micellar drug-loaded system formed by said copolymer and an anti-tumor drug. Said amphiphilic block copolymer comprises a hydrophilic segment and a hydrophobic segment, and the end group of said hydrophobic segment is end-capped with a hydrophobic group. Methoxypolyethylene glycol (or polyethylene glycol)-polyester block copolymer which has recognized safety is used as a fundamental material of the amphiphilic block copolymer of the present invention, and the terminal hydroxyl group of the polyester segment is modified with a hydrophobic group, whereby the compatibility between the drug molecule and the hydrophobic segments of the block copolymer is improved, and the interaction therebetween is enhanced. Moreover, a larger space for accommodating the drug molecules is provided. Said micelles are more effective in restricting the drug molecules inside the micellar core and preventing the drug from dissolved out of the micelles. Therefore, a drug-loaded micelle with high stability is obtained.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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