Arizona Board of Regents on Behalf of the University of Arizona
发明人:
Laurence Hurley,Vijay Gokhale,HyunJin Kang,Kui Wu
申请号：
US15779132
公开号：
US10556860B2
申请日:
2016.11.30
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula as described herein. Some aspects of the invention are based on the characterization of the effect of hTERT core promoter region mutants on the 5-12 G-quadruplex structure and its stability. It is believed that some of the compounds of the invention bind selectively to the G-quadruplex in the hTERT core promoter mutant, which results in reversal of the effect of mutant promoter activation.
