A patient specific implant alignment guide assembly includes an anatomical reference component and a guide component. The anatomical reference component includes at least one matching feature shaped and dimensioned to match and complement a specific feature of an anatomic location. The anatomical reference component further has one or more protrusions and is fabricated based on one or more images of the anatomic location where the implant is to be implanted. The guide component includes one or more attachment protrusions that are shaped and dimensioned to match and interface with the one or more protrusions of the anatomical reference component. The guide component is attached to the anatomical reference component by matching and attaching the one or more attachment protrusions of the guide component to the one or more protrusions of the anatomical reference component.