Refers to a compound of formula (i) wherein: R1 is H, F and chlorine R5 is H or C? Ch2ch2 CCh3 X is - -, - ch = CH -, among others Z1 is - C (R3) - and - N - S - is Z2 and Z3 is - - or - C (R4) and N - R3 and R4 are independently H and CH3, OCH3.Preferred compounds are: acid (3S) - 3 - [4 - [[5 - (spiro [indan - 1,4 - piperidin] - 1 - ylmethyl) - 2-thienyl] methoxy] phenyl] - 4 - inoico hex acid (3S) - 3 - [4 - [[5 - (spiro [inden - 1,4 - piperidin] methyl) - 1 - (2-furyl) methoxy] phenyl] - 4 - inoico hex among others. In addition to such a Pharmaceutical composition.Said Compound is Activator of G Protein coupled receptor 40 (GPR - 40) is useful for the treatment of DiabetesSE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: R1 ES H, F Y CLORO R5 ES H O -C?CCH3 X ES -CH2CH2-, -CH=CH-, ENTRE OTROS Z1 ES -C(R3)- Y -N Z2 ES -S- Y -O- Z3 ES -C(R4)- Y -N- R3 Y R4 SON INDEPENDIENTEMENTE H, OCH3 Y CH3. SON COMPUESTOS PREFERIDOS: ACIDO (3S)-3-[4-[[5-(ESPIRO[INDAN-1,4-PIPERIDIN]-1-ILMETIL)-2-TIENIL]METOXI]FENIL]HEX-4-INOICO ACIDO (3S)-3-[4-[[5-(ESPIRO[INDEN-1,4-PIPERIDIN]-1-ILMETIL)-2-FURIL]METOXI]FENIL]HEX-4-INOICO ENTRE OTROS. REFERIDA ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES ACTIVADOR DEL RECEPTOR 40 ACOPLADO A LA PROTEINA G (GPR-40) SIENDO UTIL PARA EL TRATAMIENTO DE LA DIABETES
