Slow release Pharmaceutical formulation comprising an outer layer comprising a blend of a First Polymer Material which is susceptible to attacks by The Colonic bacteria and a Second polymeric material which has a threshold pH 5 or higher, and the Inner Layer contains a Acid soluble polymeric material policarboxilico gastrointestinal or intestinal Fluid.
Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and the coating comprises an inner layer and an outer layer. The outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria, and a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a third polymeric material which is soluble in intestinal fluid.<；p>；LA SOLICITUD SE REFIERE A UNA FORMULACIÓ；N DE FÁ；RMACO DE LIBERACIÓ；N RETARDADA ORAL PARA SUMINISTRAR UN FÁ；RMACO AL COLÓ；N QUE COMPRENDE UN NÚ；CLEO QUE ESTÁ； RECUBIERTO POR UNA CAPA EXTERIOR, EN DONDE SE MEZCLA DOS MATERIALES POLIMÉ；RICOS Y UNA CAPA INTERIOR CON UN TERCER MATERIAL POLIMÉ；RICO； MÉ；TODO DE PREPARACIÓ；N DE LA FORMULACIÓ；N<；/p>；
