Satish Kumar Nachaegari,Chandrashekar Giliyar,Raj Patel,Nachiappan Chidambaram,Srinivansan Venkateshwaran,Mahesh V. Patel
申请号：
US15016164
公开号：
US20160193227A1
申请日:
2016.02.04
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure is drawn to oral pharmaceutical compositions and dosage forms containing select testosterone esters and related methods. In one embodiment of the present invention, an oral pharmaceutical composition for administration to subjects in need of testosterone is provided. The composition comprises a testosterone ester and a pharmaceutically acceptable carrier. The testosterone ester can have the structurewherein R is —C13H25O or —C14H27O. One or both of the esters can be present in the pharmaceutical composition. The composition is formulated such that upon single dose administration to a group of human subject, the composition provides a mean serum testosterone Cavg t12-t24 that is within about 35% to about 70% of the mean serum testosterone Cavg t0-424.
