KIM, SOOJIN,金松景,GAO, QI,高齐,高齊,YANG, FUKANG,杨福康,楊福康
申请号：
TW097130412
公开号：
TWI359813B
申请日:
2008.08.08
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
The present disclosure generally relates to a crystalline form of methyl ((1S)-1-(((2S)-2-(5-(4'-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1 H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt. The present disclosure also generally relates to a pharmaceutical composition comprising a crystalline form, as well as methods of using a crystalline form in the treatment of Hepatitis C and methods for obtaining such crystalline form.本揭示案大體係關於一種((1S)－1－(((2S)－2－(5－(4'－(2－((2S)－1－((2S)－2－((甲氧羰基)胺基)－3－甲基丁醯基)－2－吡咯啶基)－1H－咪唑－5－基)－4－聯苯基)－1H－咪唑－2－基)－1－吡咯啶基)羰基)－2－甲基丙基)胺基甲酸甲酯二鹽酸鹽之結晶型式。本揭示案大體亦關於一種包含該結晶型式的醫藥組合物，及使用該結晶型式治療C型肝炎的方法，及獲得該結晶型式的方法。
