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MATERIAU METALLIQUE ANTITHROMBOTIQUE
专利权人:
TORAY INDUSTRIES; INC.
发明人:
KADOWAKI, KOJI,FUJITA, MASAKI,SAKAGUCHI, YUKA,TANAHASHI, KAZUHIRO
申请号:
CA2979779
公开号:
CA2979779A1
申请日:
2016.03.31
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
The present invention addresses the problem of providing an antithrombotic metallic material which has improved safety against low hemolytic toxicity and can exhibit high antithrombotic properties sustainably. The present invention provides an antithrombotic metallic material comprising a metallic material of which the surface is coated with a coating material, wherein the coating material comprises a phosphonic acid derivative or a catechol derivative, a polymer containing, as a constituent monomer, a compound selected from the group consisting of an alkyleneimine, vinylamine, allylamine, lysine, protamine and diallyl dimethyl ammonium chloride and a sulfur-atom-containing compound having an anionic anticoagulant activity, the polymer is covalently bonded to the phosphonic acid derivative or the catechol derivative, the phosphonic acid derivative or the catechol derivative is bonded to the metallic material through a phosphonic acid group or a catechol group contained in the derivative, and the ratio of the amount of nitrogen atoms to the total amount of all of atoms is 4.0 to 13.0% by atom number when the surface of the antithrombotic metallic material is measured by an X-ray photoelectron spectroscopy (XPS).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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