A tissue treatment system and a treatment applicator provide multi-modality treatment of skin, tissue and organ conditions and pathologies using different types of treatment energy, alone or in combination, including radiofrequency (RF) energy and ultrasound energy to achieve multiple and different treatment effects that are tissue-specific and tissue depth- specific. The system and the applicator according to the invention selectively and fractionally and, as an option, nonfractionally, treat one or more tissue zones within a three-dimensional volume of skin or other soft tissue with one or more energy types and precisely target measured treatment energy to specific tissue types, tissue layers and/or specific depths or locations within the volume of skin or tissue. The system and the applicator can also target one or more energy types to treat a specific location or depth within a given tissue layer. The system and the applicator can provide different RF and ultrasound treatment energies that accurately affect the structure or activity of different tissue types, layers and/or depths within a given tissue zone of the skin or tissue volume in accordance with the treatment effects desired in particular tissue layers and/or at particular tissue depths to thereby selectively produce multiple and different treatment impacts.Linvention porte sur un système de traitement de tissu et sur un applicateur de traitement, lesquels système et applicateur fournissent un traitement, à modalités multiples, détats et de pathologies de la peau, de tissu et dorgane à laide de différents types dénergie de traitement, seule ou en combinaison, comprenant de lénergie radiofréquence (RF) et de lénergie ultrasonore, pour parvenir à de multiples et différents effets de traitement spécifiques à un tissu et spécifiques à une profondeur de tissu. Le système et lapplicateur selon linvention traitent de manière sélective et fractionnée et, facultativement, non fractionnée, une ou plusieurs zones d