KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY;한국생명공학연구원
发明人:
HAN, BAEK SOO,한백수,BAE, KWANG HEE,배광희,LEE, SANG CHUL,이상철,KIM, SUN YOUNG,김선영,KIM, WON KON,김원곤,OH, KYOUNG JIN,오경진,HAN, BAEK SOOKR,BAE, KWANG HEEKR,LEE, SANG CHULKR,KIM, SUN YOUNGKR,KIM, WON KONKR,OH, KYOUNG JINKR
申请号：
KR1020140129109
公开号：
KR1020160036889A
申请日:
2014.09.26
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to: a differentiation method of neural cells comprising a step of overexpressing dual-specificity phosphatase 4 (DUSP4) which is a novel neuronal marker in stem cells； a composition for promoting neural cell differentiation including the DUSP4 gene； and a pharmaceutical composition for treating cranial nerve diseases including stem cells in which the DUSP4 gene is overexpressed. The differentiation into neuronal cells can be promoted, when overexpressing the DUSP4 provided from the present invention in the stem cells. Therefore, the present invention can be widely used in the effective treatment of various cerebral nerve diseases such as Alzheimer&prime；s disease by using the stem cells in which the DUSP4 gene is overexpressed.본 발명은 신규한 신경세포 마커인 DUSP4(dual-specificity phosphatase 4)를 줄기세포에서 과발현시키는 단계를 포함하는 신경세포의 분화방법, 상기 DUSP4 유전자를 포함하는 신경세포 분화촉진용 조성물 및 상기 DUSP4 유전자가 과발현되는 줄기세포를 포함하는 뇌신경계 질환 치료용 약학 조성물에 관한 것이다. 본 발명에서 제공하는 DUSP4를 줄기세포에서 과발현시키면, 신경세포로의 분화를 촉진시킬 수 있으므로, 상기 DUSP4가 과발현되는 줄기세포를 이용할 경우, 알츠하이머 병과 같은 다양한 뇌신경계 질환의 효과적인 치료에 널리 활용될 수 있을 것이다.
