A toothbrush sanitation device includes a base with a container for immersing toothbrush bristles in a sanitizing, disinfecting or cleaning fluid and a lid. The base includes a perimeter flange with an annular protrusion and an annular cavity that are circular and concentric to the base and has a height that is 20% to 40% of the total height of the device. The container has a cylindrical inner wall with a rounded bottom and a conical outer wall, which tapers toward an open end of the container, and has one or more level tags/indications. The lid has a column and a fitting zone disposed in an open end adjacent to the column. An inner wall of the fitting zone is cylindrical, and the external taper of the container and the internal cylindricity of the fitting zone define a locking line.
