THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;MIRAGEN THERAPEUTICS, INC.
发明人:
VAN ROOIJ, EVA,OLSON, ERIC,GRUETER, CHAD
申请号：
CA2850223
公开号：
CA2850223A1
申请日:
2012.10.09
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The disclosure provides a method of regulating fatty acid or glucose metabolism in a cell by contacting the cell with a modulator of miR-208a and/or miR-208b activity or expression. The disclosure also provides a method of treating or preventing a metabolic disorder, such as obesity, diabetes, or metabolic syndrome, in a subject by administering to the subject an inhibitor of miR-208a and/or miR-208b activity or expression. Also provided is a method of enhancing or improving mitochondrial function and/or redox-homeostasis in a subject by administering to the subject an inhibitor of miR-208a and/or miR-208b activity or expression.
